The Bible teaches that the end of all things is the glory of God. "Thou art worthy, O Lord, to receive glory and honour and power: for thou hast created all things, and for thy pleasure they are and were created." (Rev.4:11). The Bible also teaches that God has forordained everything that happens - "being predestinated according to the purpose of him who worketh all things after the counsel of his own will" (Eph.1:11). God is absolutely free to purpose and plan the whole of history (including Satan and the sin of man) so that his glory is ultimately displayed in the eternal world that follows, both in showing the glory of his grace in the salvation of his people and the glory of his justice in the condemnation of unforgiven guilty sinners (see Romans 9:15-23). The reason Christians pray is because just as God has been pleased normally to use rain to cause grass to grow, so he has appointed prayer, and his answers to prayer, as an instrumental means in the outworking of his all-inclusive purpose. Even the prayers of his people are part of his plan. Thus, when Daniel knew from the prophecy of Jeremiah that the captivity of the Jews in Babylon was to last 70 years and that period was coming to an end, he still prayed (Daniel 9:1-3).
The alternative is to make man the chief end of all. The problem is that man is finite. He is not God and when he tries to pretend he is, it leads to a whole world of unreality. This is why Lew gets so frustrated and intolerant with us and avoids the basic questions. This pretence involves a whole raft of things to be ignored in order to keep up the illusion that there can be 'meaning' apart from the acknowledgemment of the Sovereign God. So many terms become meaningless in a godless framework. The most obvious is 'good' and 'evil' and 'right' and 'wrong' - is this just a matter of human concensus at any given time? Was Hitler 'evil' in any objective sense? What is 'progress' or even 'human dignity', if there is no standard outside of ourselves? If we all end up as nothing, why does what we do or experience in this world matter? If Christians are deranged - so what? We all end up as nothing anyway and life is a meaningless farce whatever a person has believed when alive; it makes no difference. And if we are purely material beings, is 'happiness' any more than a state of the nervous system and chemicals of which we are comprised?
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